Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation
نویسندگان
چکیده
منابع مشابه
Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.
Genome-wide copy number profiles were characterized in 41 primary bladder tumors using array-based comparative genomic hybridization (array CGH). In addition to previously identified alterations in large chromosomal regions, alterations were identified in many small genomic regions, some with high-level amplifications or homozygous deletions. High-level amplifications were detected for 192 geno...
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Accurate and efficient genome-wide detection of copy number variants (CNVs) is essential for understanding human genomic variation, genome-wide CNV association type studies, cytogenetics research and diagnostics, and independent validation of CNVs identified from sequencing based technologies. Numerous, array-based platforms for CNV detection exist utilizing array Comparative Genome Hybridizati...
متن کاملIdentification of copy number variants associated with renal agenesis using array-based comparative genomic hybridization
ii ACKNOWLEDGMENTS I would like to thank all members in Dr. Manak's lab, especially to Steven Butcher, Xiaojing Hong and Riley Boland who help me for numerous times in my experiments. Also, thanks to Dr. Brophy and Jason Clarke who provide patients' DNA samples and useful information for my projects. Thanks to Song Yi and Nidhi Sahni for their nice help in thesis preparation and writing. Thanks...
متن کاملArray-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors
BACKGROUND The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progression to the aggressive change of bone tissue. METHODS Genome-wide array-based comparative genomic hybridization (array CGH) was used to investigate DCNAs of 14 samples from ...
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The secondary genetic events associated with follicular lymphoma (FL) progression are not well defined. We applied genome-wide BAC array comparative genomic hybridization to 106 diagnostic biopsies of FL to characterize regional genomic imbalances. Using an analytical approach that defined regions of copy number change as intersections between visual annotations and a Hidden Markov model-based ...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2011
ISSN: 1755-8794
DOI: 10.1186/1755-8794-4-25